
GYY 4137 morpholine salt
CAS No. 106740-09-4
GYY 4137 morpholine salt( —— )
Catalog No. M23272 CAS No. 106740-09-4
GYY4137 is a novel water-soluble and slow releasing H2S donor with vasodilator and antihypertensive activity.?
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 33 | In Stock |
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10MG | 52 | In Stock |
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25MG | 83 | In Stock |
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50MG | 122 | In Stock |
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100MG | 178 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameGYY 4137 morpholine salt
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NoteResearch use only, not for human use.
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Brief DescriptionGYY4137 is a novel water-soluble and slow releasing H2S donor with vasodilator and antihypertensive activity.?
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DescriptionGYY4137 is a novel water-soluble and slow releasing H2S donor with vasodilator and antihypertensive activity.?GYY4137 also exhibits anti-inflammatory and anticancer activity.
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In VitroGYY4137 (400-800 μM) causes concentration-dependent killing of seven different human cancer cell lines (HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS) but did not affect survival of normal human lung fibroblasts (IMR90, WI-38). GYY4137 (0.1-0.5 mM) decreases LPS-induced production of nitrite (NO2?), PGE2, TNF-α and IL-6 from human synoviocytes (HFLS) and articular chondrocytes (HAC), reduces the levels and catalytic activity of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and reduced LPS-induced NF-κB activation. Cell Viability Assay Cell Line:HeLa, HCT-116, Hep G2, HL-60, MCF-7, MV4-11 and U2OS Concentration:400 or 800 μM Incubation Time:5 days Result:Significantly affected cancer cell survivability.
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In VivoGYY4137 (100-300 mg/kg; i.p.; daily for 14 days) significantly reduces the tumor volume in both animal models, in a dose-dependent manner.?In the complete Freund's adjuvant (CFA)-treated mouse, GYY4137 (50 mg/kg, i.p.) injected 1 hr prior to CFA increased knee joint swelling while an anti-inflammatory effect, as demonstrated by reduced synovial fluid myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activity and decreased TNF-α, IL-1β, IL-6 and IL-8 concentration, was apparent when GYY4137 was injected 6 hrs after CFA.?GYY4137 significantly inhibited tumor growth in the subcutaneous HepG2 xenograft model by inhibiting STAT3 activation and its target gene expression.?GYY4137 prevents nitrative stress and α-synuclein nitration in an MPTP mouse model of parkinson’s disease. Animal Model:Female, severe combined immunodeficiency (SCID) mice (bearing HL-60 or MV4-11 cells) Dosage:100, 200 and 300 mg/kg Administration:I.p.; daily for 14 daysResult:Reduced tumor volume by 52.5±9.2% and 55.3±5.7% in HL-60 and MV4–11 injected animals.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number106740-09-4
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Formula Weight376.47
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Molecular FormulaC11H16NO2PS2·C4H9NO
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Purity>98% (HPLC)
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SolubilityDMSO:12.85mg/mL
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SMILESSP(N1CCOCC1)(C2=CC=C(OC)C=C2)=S.N3CCOCC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference



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